Dr. Qin Liu
My primary research interest is to understand cell adhesion molecule cadherins function in the development of the vertebrate visual system. I have chosen to study zebrafish, which has become one of the most important animal models for studies of vertebrate development. To study cadherins function in zebrafish visual system development, we first determine their expression using in situ hybridization and/or immunocytochemical methods, followed by disrupting their expression in embryonic zebrafish using antisense morpholino oligonucleotides technology, and finally examine morphological changes in the visual structures and analyze differentiation of retinal and/or tectal neurons using multiple molecular and cellular markers. Our studies have showed that both classical cadherins (e.g. N- and R-cadherins) and protocadherins (e.g. protocadherin-17) play important and differential roles in the zebrafish retinal development.
Liu, Q. M.R. Dalman, S. Sarmah, S. Chen, Y. Chen, A.K. Hurlbut, M.A. Spencer, L. Pancoe, and J.A. Marrs. 2011. Cell adhesion molecule cadherin-6 function in zebrafish cranial and lateral line development. Dev. Dyn., 240:1716-1726.
Marrs, J.A., and Q. Liu. 2010. Cadherin adhesion functions revealed in zebrafish. In Molecular and Functional Diversities of Cadherin and Protocadherin, (K. Yoshida Ed.), Research Signpost. 2010:213-229.
Liu, Q., Y. Chen, D.D. Copeland, B. Hope, R.J. Duff, B. Rockich, and R.L. Londraville. 2010. Expression of leptin receptor gene in developing and adult zebrafish. Gen.Comp. Endocrinol. 166:346-355.
Liu, Q., Y. Chen, F. Kubota, J.J. Pan, and T. Murakami. 2010. Expression of protocadherin-19 in the nervous system of the embryonic zebrafish. Int. J. Dev. Biol., 54:905-911.
Liu, Q., Y. Chen, J.J. Pan, and T. Murakami. 2009. Expression of protocadherin-9 and protocadherin-17 in the nervous system of the embryonic zebrafish. Gene Expr. Patt., 7:490-496.
Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G. Fatkins, 2008. Cadherin-6 function in zebrafish retinal development. Dev. Neurobiol., 68:1107-1122.
Liu, Q., J.A. Marrs, R.L. Londraville, A.L. Wilson. 2008. Cadherin-7 function in zebrafish development. Cell and Tissue Res., 334:37-45.
Liu, Q., R.A. Frey, S.G. Babb-Clendenon, B. Liu, J. Francl, A.L. Wilson, J.A. Marrs, and D.L. Stenkamp, 2007. Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin-2 mutant glass onion and zebrafish cadherin-4 morphants. Exp. Eye Res., 84:163-175.
1994, Ph.D. University of Kentucky, Lexington, KY; Dissertation title: Serotonin-like Immunoreactivity in the Visual System of the Frog Rana pipiens