The research in our laboratory can be summarized by the following topics:
- Electroanalytical methods of detection of ultra-low concentrations of various analytes including both hard (metal, polymer) and soft (emulsion) nanoparticles, as well as biological macromolecules
- Electrokinetic phenomena: dielectrophoresis, electrothermal fluid flow, electrophoretic migration
- Scanning electrochemical microscopy using ac polarized microelectrodes
- Numerical simulations with COMSOL Multiphysics
The long term goal of this research is to achieve single molecule detection using electrochemical methods. In regards to this, methods of stochastic electrochemistry offer an exceptional sensitivity; however, as of now they lack the specificity of detection. In the nearest future our research efforts will be directed towards resolving the specificity problems, as well as improving further the limits of detection. We are interested in the analysis of a wide group of analytes including bacteria, viruses and macromolecules, many of which are important in medicine and national defense.
Boika, A.; Zhao, Z. First Principles of Hot-Tip Scanning Electrochemical Microscopy: Differentiating Substrates According to Their Thermal Conductivities. Electrochemistry Communications 2016, 68, 36-39.
Boika, A.; Bard, A. J. Time of First Arrival in Electrochemical Collision Experiments as a Measure of Ultra Low Concentrations of Analytes in Solution. Analytical Chemistry 2015, 87, 4341-4346.
Bard, A. J.; Boika, A.; Kwon, S. J.; Park, J. H.; Thorgaard, S. N. Stochastic Events in Nanoelectrochemical Systems. In Nanoelectrochemistry; CRC Press: 2015, pp. 241-292.
Dick, J. E.; Hilterbrand, A. T.; Boika, A.; Upton, J. W.; Bard, A. J. Electrochemical Detection of a Single Cytomegalovirus at an Ultramicroelectrode and Its Antibody Anchoring. Proceedings of the National Academy of Sciences of the U. S. A. 2015, 112, 5303-5308.
Kim, B.-K.; Boika, A.; Kim, J.; Dick, J.E.; Bard, A.J. Characterizing Emulsions by Observation of Single Droplet Collisions – Attoliter Electrochemical Reactors. Journal of the American Chemical Society 2014, 136, 4849-4852.
Boika, A.; Thorgaard, S.N.; Bard, A.J. Monitoring the Electrophoretic Migration and Adsorption of Single Insulating Nanoparticles at Ultramicroelectrodes. Journal of Physical Chemistry B 2013, 117, 4371–4380.
Baranski, A.S.; Boika, A. Ultrahigh Frequency Voltammetry: Effect of Electrode Material and Frequency of Alternating Potential Modulation on Mass Transport at Hot-Disk Microelectrodes. Analytical Chemistry 2012, 84, 1353-1359.
Boika, A.; Baranski, A.S. Numerical Simulations of Phenomena Observed at Hot Microelectrodes: Inlaid Microdisk. Electrochimica Acta 2011, 56, 7288-7297.
Boika, A.; Baranski, A.S. Dielectrophoretic and Electrothermal Effects at Alternating Current Heated Disk Microelectrodes. Analytical Chemistry 2008, 80, 7392-7400.