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| DANIEL J. SMITH |
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Professor
B.S., 1968 Wisconsin State University
Ph.D., 1974, University of California, Berkeley
Postdoctoral fellow, 1974-1976, University of California, Los Angeles
Research professor, NEOUCOM
Professor, Institute for Biomedical Engineering
Member of the Maurice Mortong Institute of Polymer Science |
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Office: KNCL 407
(330) 972-7414 |
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Lab: KNCL 409
(330) 972-8394 |
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| Email: djs5@uakron.edu |
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| Website: |
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| Research Interests |
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The two primary research directions in my group are focused on mechanisms involved in wound repair and the design of novel biodegradable and/or biocompatible polymers which deliver nitric oxide to biological systems.
Wound repair in humans can be accelerated by application of well-designed dressings or by the addition of growth hormones or factors. My group is developing new methods that can be used in these dressings, including a novel method to deliver growth factors to wounds. This delivery system is a genetically engineered biological bandage, which is capable of providing growth factors to the wound and accelerate repair. Various cell lines have been developed that overproduce growth factors and can live inside a bandage, secreting these factors directly to the wound.
Novel synthetic polymers also are being developed that are capable of releasing nitric oxide. Site specific delivery of nitric oxide to humans may prove useful in the treatment of various diseases. In collaboration with other groups across the country, these polymers are being evaluated for their ability to prevent restenosis, viral and bacterial infections, respiratory distress and cancer. These polymers release nitric oxide, then biodegrade to natural products.
Underlying all of our studies is an effort to understand the biochemical mechanisms involved in wound repair and nitric oxide function. |
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| Selected Publications |
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S.Y. Silva, L.C. Rueda, M.Lopez, D. Ivan, C.F. Rueda-Clausen, D.J. Smith, G. Munoz, H. Mosquera, F. Silva, A. Buitrag, H. Diaz, P. Lopez-Jaramilo, Double Blind, Randomized Control Trial, to Evaluate the Effectiveness of a Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis, Trials, 2006, 1745-1752.
"Evaluation of Three New Hydrocolloid Dressings: Retention of Dressing Integrity and Biodegradability of Absorbent Components Attenuate Inflammation," Smith, D.; Chakravarthy, D.; Schmidt, S.; and Rodway, N., J. of Biomedical Materials Research, 1994, 28, 1165-1173.
"Metal-binding Properties of Poly(Quadrol-Methacrylate) Hydrogels," Fulton, J., and Smith, D.J., Polym. Bull., 1994, 32, 705-12.
"Nitric Oxide Synthesis is Supressed in Steroid-impaired and Diabetic Wounds," Bulgrin, J.; Sabani, M.; and Smith, D.J., Wounds, 1995, 7(2), 48-57.
"NO Donors: A Continuing Opportunity in Drug Design in Nitric Oxide: Biochemistry Molecular Biology, and Therapeutic Implications," Hanson, S.R.; Hutsell, T.C.; Keefer, L.K.; Mooradian, D.L.; Smith, D.J.; (Ignarro, L., and Murad, F., eds.), 1995, 34, 383.
"Preparation of Dextran-based Degradable Absorbent Suitable for Wound Healing Applications," Chakravarthy, D. and Smith, D.J., J. Bioactive and Compatible Polymers, 1995, 10(4), 313.
"A Noninvasive, Three-dimensional, Diagnostic Laser Imaging System for Accurate Wound Analysis," Physiol. Meas., 1996, 17, 71-79.
"Enhancement of Wound Repair with a Topically Applied Nitric Oxide-releasing Polymer," Bulgrin, J.; Sabani, M.; Pulfer, S.; and Smith, D.J., Wound Repair and Regeneration, 1996, 4(3), 353.
"Nitric Oxide-releasing Polymers Containing the [N(O)NO]- Group," Smith, D.J.; Chakravarthy, D.; Pulfer, S.; Simmons, M.L.; Hrabie, J.A.; Citro, M.L.; Saavedra, J.E.; Davies, K.M.; Hutsell, T.C.; Mooradian, D.L.; Hanson, S.R.; and Keefer, L.K., J. of Med. Chem., 1996, 39(5), 1148-1156.
"Tissue-selective Delivery of Nitric Oxide Using Diazeniumdiolates (formerly "NONOates")," Keefer, L.K.; Smith. D.J.; Pulfer, S.; Hanson, S.R.; Saavedra, J.E.; Billiar, T.R.; and Roller, P.P., Portland Press Proc., 1996, 10, 335.
"Incorporation of Nitric Oxide-releasing Cross-linked Polyethyleneimine Microspheres into Vascular Grafts," Pulfer, S.K.; Ott, D.; and Smith, D.J., J. of Biomed. Materials Res. 1997, 37/2 182.
"Synthesis of Lipophilic 1-substituted Diazen-1-ium-1,2-diolates," Roselle, D.C., and Smith, D.J., Chem. Pharm. Bull. (Tokyo), 1997, 45(4), 747-749.
"Controlled Drug Delivery Challenges and Strategies," ed. K. Park, "Drug Delivery Using Genetically Engineered Cell Implants," Eckert, R.L.; Smith, D.J.; and Schafer, I.A., American Chemical Society, Washington, D.C., 347-352, 1997.
"Transdermal Delivery of Nitric Oxide from Diazeniumdiolates," Smith, D.J., and Simmons, M.L., J. Controlled Release, 1998, 51, 153-159. |
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