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| WILEY J. YOUNGS |
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Professor
B.A., 1972, SUNY at Albany
Ph.D., 1980, SUNY at Buffalo
Postdoctoral fellow, 1980-1983, Northwestern University
Assistant professor, 1983-1989, Case Western Reserve University
Associate Professor, 1989-1990, Case Western Reserve University |
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Office: KNCL 107
(330) 972-5362 |
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Lab: KNCL 109
(330) 972-8395 |
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| Email: youngs@uakron.edu |
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| Website: http://gozips.uakron.edu/~youngs/ |
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| Research Interests |
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A. Heterocyclotriynes: Funded by NSF.
We have previously reported the synthesis of the tetraplatinum butadiyne square. Such a heterocyclyne square with butadiyne fragments at the edges is a good ligand for the formation of tweezer complexes, as the butadiyne-Pt-butadiyne bond angle is almost 90¡C as indicated from the crystal structure of the precursor of such a square. This makes such a square a good candidate to host silver via tweezer effect. We have reported the synthesis, characterization and the first crystal structures of tweezer complexes where four silver cations coordinated at the four corners of the tetraplatinum-butadiyne square. The molecular model of these tetrasilver tweezer complexes showed that there is a plenty of room in the cavity of the tetraplatinum square with the four silver cations at the corners. |
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B. Synthesis of Metallocarbeneporphyrinoids and Their Metal Complexes:
The overall specific aim of this project as funded by the American Heart Association is the development of metal complexes of a new series of ligands as imaging agents for hypoxic tissue following heart attack or stroke using Positron Emission Tomography (PET). The first objective of this proposal is the synthesis of macrocycles in which one or more pyrrole units in a porphyrinogen or porphyrin ring have been replaced with N-heterocyclic carbene units. The replacement of the pyrrole units in the porphyrinogen or porphyrin core with N-heterocyclic carbene units will produce two new classes of macrocycles, which will be termed carbeneporphyrinogens and carbeneporphyrins. These compounds demonstrate a completely new way to modify the porphyrin chromophore. The second objective of this project is the synthesis of metal complexes of these new ligands to from metallocarbeneporphyrinogens and metallocarbeneporphyrins. The stability of the metal complexes used as imaging and therapeutic agents is extremely important when considering possible applications such as Positron Emission Tomography (PET). A major problem in these areas is dissociation of the metal from the metal complex that is administered to the patient. This can leave radioactive elements in the body of the patient. N-heterocyclic carbenes bind very strongly to transition and main group metals and current data indicate that carbeneporphyrins will bind more strongly to metal centers than do other macrocycles currently used in imaging applications. |
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| Selected Publications |
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"Synthesis and Structural Characterization of an Imidazolium Linked Cyclophane and the Silver Complex of a N-Heterocyclic Carbene Linked Cyclophane," Garrison, J.C.; Simons, R.S.; Talley, J.M.; Wesdemiotis, C.; Tessier, C.A.; Youngs, W.J.; Organometallics 2001, 20, 1276.
"ortho-Arene Cyclynes, Related Heterocyclynes and Their Metal Chemistry," Youngs, W.J.; Tessier, C.A. and Bradshaw, J.D.; Chem. Rev. 1999, 3153-3180. For Electronic Publication go to http://dx.doi.org/10.1021/om010085s).
"The Synthesis of Tri(2,5-dialkynylthieno) cyclotriynes, Tri(4,5-dialkoxyphenyl) cyclotriynes, and Tetra(4,5-dialkoxy-phenyl) cyclotetraynes with long chain alkyl substituents, and the Nickel and Cobalt Complexes of Tri(4,5-didodecyloxyphenyl) cyclotriyne," Zhang, D.; McConville, D.B.; Tessier, C.A.; Youngs, W.J.; Chemistry of Materials, 1999, 3050-3057.
"Synthesis and Structural Characterization of the Mono-Silyl Platinum(II) Complex: Cis-(2,6-Mes2C6H3(H)2Si)Pt(H)(PPr3)2" Simons, R.S.; Sanow, L.M.; Galat, K.J.; Tessier, C.A.; and Youngs, W.J., Organometallics, 2000, 19, 3994-3996. |
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