Dr. William J. Landis
G. Stafford Whitby Chair
Department of Polymer Science
The Landis Laboratory conducts investigations of connective tissue molecular biology, biochemistry, structure and function. It seeks to understand the manner by which several such connective tissues become mineralized to form the vertebrate skeleton and dentition and also the means whereby some connective tissues remain unmineralized (normal skin, tendon, and ligament, for example). It also examines approaches to design and develop tissue-engineered connective tissues such as models of human bone, calcifying cartilage, and tendon for digits; human cartilage for ear and knee meniscus constructs; and other tissues and organs. These research endeavors have branched into additional work in the areas of polymer science and biomaterials to examine the interactions between biodegradable and biocompatible polymeric scaffolds and the cells, cytokines, and growth factors utilized in tissue engineering. The Landis Laboratory further is concerned with effects of mechanical, gravitational and electromagnetic forces on calcified tissues, including a number of projects supported by the National Aeronautics and Space Administration in its efforts to understand bone loss in astronauts subjected to longer term spaceflight. Finally, the Landis Laboratory focuses on a number of orthopaedic pathologies, including osteogenesis imperfecta, osteoporosis, osteopetrosis, osteoarthritis, slipped capital femoral epiphysis, hypothyroidism, dysplasia, and clubfoot.
The Landis Laboratory current members are Robin Jacquet, M.S. (laboratory manager), Elizabeth Lowder, M.S. (senior research associate), Seika Matsushima, M.D. (visiting research fellow), Jessica Kemppainen, Ph.D. (postdoctoral fellow), Ling Chen, M.S. (graduate student), and Noritaka Isogai, M.D., Ph.D. (visiting professor).