Dr. Bing Yu
Dr. Bing Yu is an Assistant Professor in Biomedical Engineering at The University of Akron since 2012. He received his Ph.D. in Electrical Engineering from Virginia Tech in 2005 and worked in the Department of Biomedical Engineering at Duke University as a Research Associate (2005-08), Senior Research Scientist (2008-10) and Research Assistant Professor (2010-2012). Dr. Yu has been the PI/co-PI of multiple NIH grants and developed several noninvasive or minimally invasive optical spectroscopy techniques. His research in tissue optical spectroscopy and imaging has resulted in over 20 peer-reviewed journal articles, 2 book chapters, 30 conference abstracts, and 6 US/international patents or applications. He has also co-founded Zenalux Biomedical, a biomedical device company in North Carolina. Dr Yu’s current research focuses on tissue optics, optical spectroscopy and imaging, image-guide optical biopsy, miniature and cost-effective optical devices for global health, and biomedical optical sensors.
Dr. Yu’s Ph.D. research focused on fiber optic sensors and instrumentation based on white-light interferometry for harsh environments. His study has led to the invention of a thermally tunable optical filter (TOF) and the new method of using TOF as a cost-effective demodulation scheme for white-light interferometry (WLI). His work on diaphragm-based Fabry-Perot interferometric (DB-FPI) sensors for partial discharge detection in high voltage power transformers has attracted a significant amount of national and international attention in the field.
During his tenure at Duke University Dr. Yu has developed several noninvasive or minimally invasive optical spectroscopy and spectral imaging techniques for biomedical applications. He has developed a smart fiber optic sensor that can significantly improve the portability, accuracy and repeatability of in vivo tissue optical spectroscopy. The smart sensor is currently investigated for oral and cervical cancer diagnosis in the developing world. The spectral imaging system he recently developed can simultaneously acquire full reflectance spectra and provide real-time diagnosis from 49 individual tissue sites. The device is being evaluated for intraoperative assessment of breast tumor margins in a 200-patient clinical trial in the Duke University Hospital. Dr. Yu has also studied the use of a side-firing fiber optic sensor based on frequency-domain near-infrared spectroscopy (FD-NIRS) for cancer diagnosis during image-guided breast core-needle biopsy and monitoring of tumor hypoxia in animal models.
Bing Yu, Daron G. Ferris, and Vivek Krishna Nagarajan, “Mobile Fiber-Optic Sensor for Detection of Oral and Cervical Cancer in Developing World”, in Mobile Health (mHealth) Technologies, Editors Avraham Rasooly and Keith E. Herold, in press.
Bing Yu and Nirmala Ramanujam, “Quantitative Diffuse Reflectance Imaging of Tumor Margins”, in Biomedical Biophotonics Handbook, Editor-in-Chief Tuan Vo-Dinh, 2nd Edition, in press.
Bing Yu, Daron G. Ferris, Yang Liu and Vivek K. Nagarajan, “Emerging Optical Techniques for Detection of Oral, Cervical and Anal Cancer in Low-Resource Settings”, Austin Journal of Biomedical Engineering, Vol. 1, Issue 2:15, 2014. (Invited review article)
Bing Yu, Amy Shah, Vivek K. Nagarajan, and Daron G. Ferris, “Diffuse reflectance spectroscopy of epithelial tissue with a smart fiber-optic probe,” Biomedical Optics Express Vol. 5, Iss. 3, pp. 675–689 (2014).
Justin Y. Lo, J. Quincy Brown, Sulochana Dhar, Bing Yu, Gregory M. Palmer, Nan M. Jokerst, and Nirmala Ramanujam, “Wavelength optimization for quantitative spectroscopic imaging of breast tumor margins,” PLoS ONE 8(4): e61767. doi:10.1371/journal.pone.0061767 (2013).
Sulochana Dhar, Justin Y. Lo, Greg Palmer, Martin A. Brooke, Brandon Nichols, Bing Yu, Nimmi Ramanujam, and Nan M. Jokerst, “A Diffuse Reflectance Spectral Imaging System for Tumor Margin Assessment Using Custom Annular Photodiode Arrays,” Biomedical Optics Express, Vol. 3, Issue 12, pp. 3211-3222 (2012).
Bing Yu, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, and Mark W. Dewhirst, “Measuring Tumor Cycling Hypoxia and Angiogenesis using a Side-firing Fiber Optic Probe,” Journal of Biophotonics, Dec 14, 2012, doi: 10.1002/jbio.201200187.
Vivide T.C. Chang, Delson Merisier, Bing Yu, David K. Walmer, and Nirmala Ramanujam, “Towards a field-compatible optical Spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure,” Optics Express, Vol. 19, Iss. 19, pp. 17908–17924 (2011).
B. Yu, H.L. Fu and N. Ramanujam, “Instrument-Independent Diffuse Reflectance Spectroscopy,” Journal of Biomedical Optics, vol. 16(1): p. 011010 (2011).
H.L. Fu, B. Yu, J.Y. Lo, G.M. Palmer, T.F. Keuch, and N. Ramanujam, “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues,” Optics Express, Vol. 18, Issue 12, pp. 12630-12645 (2010).
J.Q. Brown, T.M. Bydlon, L.M. Richards, B. Yu, S.A. Kennedy, J. Geradts, L.G. Wilke, M. Junker, J. Gallagher, W. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” Journal of Selected Topics in Quantum Electronics, vol. 16(3), pp. 530-544, 2010.
T.M. Bydlon, S.A. Kennedy, L.M. Richards, J.Q. Brown, B. Yu, M.S. Junker, J. Gallagher, J. Geradts, L.G. Wilke, and N. Ramanujam, “Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins”. Optics Express, Vol. 18, Issue 8, pp. 8058-8076 (2010).
J.E. Bender, A.B. Shang, E.W. Moretti, B. Yu, L.M. Richards and N. Ramanujam, “Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study,” Optics Express, Vol. 17, Issue 26, pp. 23396-23409 (2009).
C. Zhu, E.S. Burnside, G.A. Sisney, L.R. Salkowski, J.M. Harter, B. Yu and N. Ramanujam, “Fluorescence spectroscopy: an adjunct diagnostic tool to image-guided core needle biopsy of the breast,” IEEE Trans Biomed Eng. 2009 Oct;56(10):2518-28.
J.Y. Lo, B. Yu, H.L. Fu, J.E. Bender, G.M. Palmer, T.F. Kuech and N. Ramanujam, “A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes,” Optics Express. 17 (3):1372-1384, 2009.
B. Yu, J.Y. Lo, T.F. Kuech, G.M. Palmer, J.E. Bender, N. Ramanujam, “A Cost-Effective Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering In Vivo,” Journal of Biomedical Optics, Vol. 13, No. 6, 2008.
B. Yu, H.L. Fu, T.M. Bydlon, J.E. Bender and N. Ramanujam, “Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe,” Optics Letters, Vol. 33, Issue 16, pp. 1783-1785 (2008).
B. Yu, E.S. Burnside, G.A. Sisney, J.M. Harter, C. Zhu, A.H. Dhalla and N Ramanujam, "Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing image-guided core-needle biopsy," Optics Express 15, pp. 7335-50 (2007).
B. Yu, A. Wang, and G.R. Pickrell, “Analysis of Fiber Fabry-Perot Interferometric Sensors Using Low-Coherence Light Sources,” Journal of Lightwave Technology, vol. 24, no. 4. pp. 1758-67 (2006).
B. Yu, A. Wang, G.R. Pickrell, and J. Xu, “Tunable Optical Filter Based White Light Interferometry for Sensing,” Optics Letters, vol. 30, no. 12, pp.1452-54 (2005).
B. Yu, G.R. Pickrell, and A. Wang, “Thermally Tunable Extrinsic Fabry-Perot Filter,” IEEE Photonics Technology Letters, vol. 16, no. 10, pp. 2296-98 (2004).
B. Yu and A. Wang, “Grating-assisted Demodulation of Interferometric Optical Sensors”, Applied Optics, vol. 42, no. 34, pp. 6824-29 (2003).
B. Yu, D.-W. Kim, J. Deng, H. Xiao, and A. Wang, “Fiber Fabry-Perot sensors for detection of partial discharges in power transformers ”, Applied Optics, Vol.42, No.16, pp. 3241-50 (2003).
B. Yu and B. Cai, “The Application Techniques of WDM in Optical SDH Communication Systems,” Optical Communication Technology, vol. 24, no. 86, pp.13-18, (2000) (in Chinese).
Ph.D. in Electrical Engineering, Virginia Tech, 2005; M.S./B.S. in Optoelectronics Technology, University of Electronic Science and Technology of China, 1989/1994.