Dr. Bing Yu
Dr. Bing Yu received his Ph.D. in Electrical Engineering from Virginia Tech in 2005. He joined Duke University as a Postdoctoral Research Associate in Biomedical Engineering in 2005, and was promoted to Senior Research Scientist in 2008 and then Research Assistant Professor in 2010. Between 2006 and 2012, Dr. Yu has been a Founding Principal Engineer at Zenalux Biomedical, Inc. (formerly Endls Optics, Inc.), a biomedical device company in North Carolina. In 2012, Dr. Yu has accepted an Assistant Professor in the Department of Biomedical Engineering at The University of Akron.
Dr. Yu’s Ph.D. research focused on fiber optic sensors and instrumentation based on white-light interferometry for harsh environments. His study has led to the invention of a thermally tunable optical filter (TOF) and the new method of using TOF as a cost-effective demodulation scheme for white-light interferometry (WLI). His work on diaphragm-based Fabry-Perot interferometric (DB-FPI) sensors for partial discharge detection in high voltage power transformers has attracted a significant amount of national and international attention in the field.
During his tenure at Duke University Dr. Yu has developed a number of noninvasive or minimally invasive optical spectroscopy and spectral imaging technologies for biomedical applications. He has developed a smart fiber optic sensor that can significantly improve the portability, accuracy and repeatability of in vivo tissue optical spectroscopy. The smart sensor is currently investigated for oral and cervical cancer diagnosis in the developing world. The spectral imaging system he recently developed (with Dr. Quincy Brown) can simultaneously acquire full reflectance spectra and provide real-time diagnosis from 49 individual tissue sites. The device is being evaluated for intraoperative assessment of breast tumor margins in a 200-patient clinical trial in the Duke University Hospital. Dr. Yu has also studied the use of a side-firing fiber optic sensor based on frequency-domain photon migration for cancer diagnosis during image-guided breast core-needle biopsy and tumor cycling hypoxia in animal models.
In the last five years Dr. Yu’s research in Biophotonics has attracted multimillion dollar NIH funding and resulted in over 15 peer-reviewed publications and 5 US/international patents or patent applications.
Current Research Interests
Optical spectroscopy and imaging for cancer diagnostics and therapeutics
Miniature and cost-effective optical devices for global health
Image-guide optical biopsy
Tumor hypoxia and metastasis
Fiber optic sensors and instrumentation
B. Yu, J.Q. Brown, T.M. Bydlon, M. Junker, J. Geradts, Scott Pruitt, and N. Ramanujam, “A 49-channel Diffuse Reflectance Imaging System for Intraoperative Detection of Breast Tumor Margins,” under preparation.
S. Dhar, J.Y. Lo, G. Palmer, M.A. Brooke, B. Nichols, B. Yu, N. Ramanujam, and Nan M. Jokerst, “A Diffuse Reflectance Spectral Imaging System for Tumor Margin Assessment Using Custom Annular Photodiode Arrays,” under preparation.
B. Yu, G.M. Palmer, B. Wang, A. Shah and N. Rajaram, N. Ramanujam, “Measuring Tumor Cycling Hypoxia and Angiogenesis using a Side-firing Fiber Optic Probe,” under preparation.
J.Y. Lo, J.Q. Brown, S. Dhar, B. Yu, N.M. Jokerst, and N. Ramanujam, “Wavelength optimization for quantitative spectroscopic imaging of breast tumor margins,” under review.
J.Y. Lo, S. Dhar, B. Yu, M.A. Brooke, T.F. Kuech, N.M. Jokerst and N. Ramanujam, "Diffuse reflectance spectral imaging for breast tumor margin assessment", Proc. SPIE 8214, 821407 (2012).
V.-T.C. Chang, D. Merisier, B. Yu, D.K. Walmer, and N. Ramanujam, “Towards a field-compatible optical Spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure,” Optics Express, Vol. 19, Iss. 19, pp. 17908–17924 (2011).
B. Yu, H.L. Fu and N. Ramanujam, “Instrument-Independent Diffuse Reflectance Spectroscopy,” Journal of Biomedical Optics, vol. 16(1): p. 011010 (2011).
S. Dhar, J.Y. Lo, B. Yu, T. Tyler, M.A. Brooke, T.F. Kuech, N. Ramanujam, N.M. Jokerst, “A custom wide-field spectral imager for breast cancer margin assessment,” Proceedings of IEEE Photonics Society Annual Meeting, accepted 2011.
J.Y. Lo, B. Yu, H. Fu, T.F. Kuech and N. Ramanujam, “A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering,” Proceedings of SPIE Vol. 7890, 78900B (2011).
H.L. Fu, B. Yu, J.Y. Lo, G.M. Palmer, T.F. Keuch, and N. Ramanujam, “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues,” Optics Express, Vol. 18, Issue 12, pp. 12630-12645 (2010).
J.Q. Brown, T.M. Bydlon, L.M. Richards, B. Yu, S.A. Kennedy, J. Geradts, L.G. Wilke, M. Junker, J. Gallagher, W. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” Journal of Selected Topics in Quantum Electronics, vol. 16(3), pp. 530-544, 2010.
T.M. Bydlon, S.A. Kennedy, L.M. Richards, J.Q. Brown, B. Yu, M.S. Junker, J. Gallagher, J. Geradts, L.G. Wilke, and N. Ramanujam, “Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins”. Optics Express, Vol. 18, Issue 8, pp. 8058-8076 (2010).
J.E. Bender, A.B. Shang, E.W. Moretti, B. Yu, L.M. Richards and N. Ramanujam, “Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study,” Optics Express, Vol. 17, Issue 26, pp. 23396-23409 (2009).
C. Zhu, E.S. Burnside, G.A. Sisney, L.R. Salkowski, J.M. Harter, B. Yu and N. Ramanujam, “Fluorescence spectroscopy: an adjunct diagnostic tool to image-guided core needle biopsy of the breast,” IEEE Trans Biomed Eng. 2009 Oct;56(10):2518-28.
J.Y. Lo, B. Yu, H.L. Fu, J.E. Bender, G.M. Palmer, T.F. Kuech and N. Ramanujam, “A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes,” Optics Express. 17 (3):1372-1384, 2009.
B. Yu, J.Y. Lo, T.F. Kuech, G.M. Palmer, J.E. Bender, N. Ramanujam, “A Cost-Effective Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering In Vivo,” Journal of Biomedical Optics, Vol. 13, No. 6, 2008.
B. Yu, H.L. Fu, T.M. Bydlon, J.E. Bender and N. Ramanujam, “Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe,” Optics Letters, Vol. 33, Issue 16, pp. 1783-1785 (2008).
B. Yu, E.S. Burnside, G.A. Sisney, J.M. Harter, C. Zhu, A.H. Dhalla and N Ramanujam, "Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing image-guided core-needle biopsy," Optics Express 15, pp. 7335-50 (2007).
B. Yu, A. Wang, and G.R. Pickrell, “Analysis of Fiber Fabry-Perot Interferometric Sensors Using Low-Coherence Light Sources,” Journal of Lightwave Technology, vol. 24, no. 4. pp. 1758-67 (2006).
B. Yu, A. Wang, G.R. Pickrell, and J. Xu, “Tunable Optical Filter Based White Light Interferometry for Sensing,” Optics Letters, vol. 30, no. 12, pp.1452-54 (2005).
X. Wang, J. Xu, B. Yu, K.L. Cooper, A. Wang, “Implementation of nondestructive Young's modulus measurement by miniature optical sensors,” Proceedings of SPIE Vol. 5998, 23-26 Oct. 2005.
J. Xu, G.R. Pickrell, X. Wang, B. Yu, K.L. Cooper, A. Wang, “Vacuum-sealed high temperature high bandwidth fiber optic pressure and acoustic sensors,” Proceedings of SPIE Vol. 5998, 23-26 Oct. 2005.
X. Wang, J. Xu, Y. Zhu, B. Yu, M. Han, K.L. Cooper, G.R. Pickrell, A. Wang, A. Ringshia, W. Ng, “Verifying an all fused silica miniature optical fiber tip pressure sensor performance with turbine engine field test,” Proceedings of SPIE Vol. 5998, 23-26 Oct. 2005.
B. Yu, G.R. Pickrell, and A. Wang, “Thermally Tunable Extrinsic Fabry-Perot Filter,” IEEE Photonics Technology Letters, vol. 16, no. 10, pp. 2296-98 (2004).
J. Xu, G.R. Pickrell, B. Yu, M. Han, Y. Zhu, X. Wang, K.L. Cooper, and A. Wang, “Epoxy-free high temperature fiber optic pressure sensors for gas turbine engine applications,” Proc. of SPIE, Sensors for Harsh Environments, Edited by Anbo Wang, Vol. 5590, 2004.
Y. Zhu, G.R. Pickrell, X. Wang, J. Xu, B. Yu, M. Han, K.L. Cooper, A. Wang, A. Ringshia, and W. Ng, “Miniature fiber-optic pressure sensor for turbine engine,” Proc. of SPIE, Sensors for Harsh Environments, Edited by Anbo Wang, Vol. 5590, 2004.
X. Chen, B. Yu, Y. Zhu and A. Wang, “Deep wet etching of fused silica material for fiber optic sensor fabrication,” Proc. of the SPIE, vol. 5342, pp. 128-136, 2004.
B. Yu, G.R.. Pickrell and A. Wang, “Grating-assisted Operation-Point Tuning for Fiber-Optic Fabry-Perot Interferometric Sensors,” Proc. of the SPIE, vol. 5272, pp. 41-48, 2004.
B. Yu and A. Wang, “Grating-assisted Demodulation of Interferometric Optical Sensors”, Applied Optics, vol. 42, no. 34, pp. 6824-29 (2003).
B. Yu, D.-W. Kim, J. Deng, H. Xiao, and A. Wang, “Fiber Fabry-Perot sensors for detection of partial discharges in power transformers ”, Applied Optics, Vol.42, No.16, pp. 3241-50 (2003).
B. Yu and B. Cai, “The Application Techniques of WDM in Optical SDH Communication Systems,” Optical Communication Technology, vol. 24, no. 86, pp.13-18, (2000) (in Chinese).
Bing Yu and Nirmala Ramanujam, “Smart fiber optic sensor system for quantitative tissue optical spectroscopy,” US patent application No. 13/513,458 and International application No. PCT/US2010/059140.
Bing Yu and Nirmala Ramanujam, “Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe,” US patent application No. 20110295541 and International Application No. PCT/US2009/041857.
Bing Yu, Nirmala Ramanujam, and Justin Y. Lo, “A diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering,” US patent application No. 20110105865 and International Application No. PCT/US2009/041732.
Nirmala Ramanujam, Bing Yu, J. Quincy Brown, “System and methods for spectral analysis of a tissue mass using an instrument, an optical probe and a Monte Carlo or Diffusion algorithm,” US patent application No. 20110112435 and International Application No. PCT/US2008/078186.
Nirmala Ramanujam, Bing Yu and J. Quincy Brown, “Optical spectral imaging for intra-operative margin assessment,” US patent application No. 20110059016 and International Application No.: PCT/US2008/078194.
Bing Yu and Anbo Wang, “Q-point Stabilization for Linear Interferometric Sensors Using Tunable Diffraction Grating,” US patent application No. 20050231728.
Ph.D. in Electrical Engineering, Virginia Tech, 2005; M.S./B.S. in Optoelectronics Technology, University of Electronic Science and Technology of China, 1989/1994.