Profile

Dr. Yang H. Yun

Dr. Yang H. Yun

Title: Associate Professor
Department: Biomedical Engineering
Office: OLRC, 301D
Phone: 330-972-6619
Fax: 330-374-8834
Email: yy@uakron.edu
Website: http://gozips.uakron.edu/~yy


Biography

Professor Yun received his doctoral degree at the University of Memphis. He then accepted a postdoctoral fellowship at the State University of New York at Stony Brook, where he investigated non-viral gene therapy using novel biomaterials. In the Fall of 2004, he became an Assistant Professor in the Department of Biomedical Engineering at the University of Akron and continued his research into gene therapy. In addition, Dr. Yun developed research programs in targeted drug-delivery systems for cancer, nanotechnology for cystic fibrosis and other infectious diseases, and biodegradable polyurethanes for tissue engineering. His research is supported by extramural funds from NIH, NSF, ABIA and industry, which include the prestigious NSF CAREER award. Recently, the book entitled “Nanotechnology in Tissue Engineering and Regenerative Medicine” featured his data as the cover art. Dr. Yun was promoted to an Associate Professor in the Fall of 2010.


Research Accomplishments

Research Interests

Patents

Y. H. Yun, D. Eward, and A. Calabro, “Gene Delivery Devices for Preventing Scar Formation in Ocular Tissues,” Disclosure filed on 9/10.

Y. H. Yun, W. J. Youngs, M. J. Panzer, “Tissue-engineering scaffold that accelerates wound healing and prevents infections,” Disclosure filed on 9/10.

Y. H. Yun, K. N. Shah, C. Tsai, and T. Miller, “Hyaluronan-Alkyne Ester; A New Biomolecule,” Disclosure filed on 1/10.

Y. H. Yun
and K. N. Shah, “Carbohydrate-Alcohol ester,” US provisional patent number 61/474,008.

Y. H. Yun, J. A. Smolen, R. E. Nemer, and P. N. Shah, “Magnetic Stirring Apparatus for In Situ Mixing and Formation of Unique Polymer-Shell Morphologies During Electrospinning,” US provisional patent number 61/321,698.

Y. H. Yun, A. Ditto, and S. Lopina, “Materials and Methods for Introducing Genetic Materials to Living Cells,” International patent application number PCT/US2007/024075 filed on 11/16/08.

W. Chen, G. R. Gaudette, H. Jiang, A. S. Saltman, and Y. H. Yun, “Biodegradable Polymer Device,” US patent application number 10/364,877 filed on 8/12/04.

Publications

D. Nasser, A. Stein, C. B. Clemons, J. P. Wilber, G. Young, Y. H. Yun, A. J. Ditto, M. Deblock, M. J. Panzer, W. Youngs, A. Milsted, C. Cannon, and J. G. Leid “Delivery of Silver-Based Antimicrobials to the Lung via Nebulization: Basic Concepts,” Computational and Mathematical Methods in Medicine (Submitted, Manuscript # 431385).

J. K. Miller, J. S. Brantner, H. T. Badawy, P. Wagers, C. B. Clemons, K. L. Kreider, A. Milsted, J. P. Wilber, Y. H. Yun, W. J. Youngs, and G. Young, “Mathematical modeling of Pseudomonas aeruginosa biofilm growth and treatment in the cystic fibrosis lung,” Mathematical Medicine and Biology (Accepted, Manuscript # MMB-12-079). PMID: 23518337.

A. Stine, D. Nassar, J. Miller, C. Clemons, J. Wilber, G. Young, Y. H. Yun, C. Cannon, J. Leid, W. Youngs, and A. Milsted, “Modeling the Response of a Biofilm to Silver-Based Antimicrobial,” Mathematical Biosciences, vol. 244 (1), p. 23-39, 2013. DOI: 10.1016/j.mbs.2013.04.006.

P. N. Shah and Y. H. Yun, “Cellular interactions with biodegradable polyurethanes formulated from L-tyrosine,” Journal of Biomaterials Applications, vol. 27 (8), p. 1017-1031, 2013. PMID: 22207610.

A. J. Ditto,* J. J. Reho,* J. A. Smolen, K. N. Shah, J. H. Holda, R. J. Ramirez, and Y. H. Yun, “In Vivo Non-viral Gene Delivery with Rapidly Degrading L-Tyrosine Polyphosphate Nanoparticles,” Molecular Pharmaceutics, vol. 10 (5), p. 1836-1844. 2013. *Co-first Authors. PMID: 23510151.

A. J. Ditto, N. K. Robishaw, M. J. Panzner, K. N. Shah, W. J. Youngs, and Y. H. Yun, “Targeting cancer with L-tyrosine polyphosphate nanoparticles decorated with folic acid and their attachment under physiological flow,” Molecular Pharmaceutics, vol. 9 (11), p. 2961-3410, 2012. PMC3518442.

J. K. Miller, R. Neubig, C. B. Clemons, K. L. Kreider, J. P. Wilber, G. W. Young, A. J. Ditto, Y. H. Yun, A. Milstead, H. T. Badawy, M. J. Panzer, W. J. Youngs, and C. L. Cannon, “Nanoparticle Deposition onto Biofilms,” Annals of Biomedical Engineering, vol. 41 (1), p. 53-67, 2013. PMC3524401.

J. J. Reho, J. D. Toot, J. Peck, J. Novak, Y. H. Yun, and R. J. Ramirez, “Increased Myogenic Reactivity of Uterine Arteries from Pregnant Rats with Reduced Uterine Perfusion Pressure,” Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, vol. 2 (2), p. 106-114, 2012. PMC3366595.

J. G. Leid, A. J. Ditto,* A. Knapp, P. N. Shah, B. D. Wright, R. Blust, L. Christensen, C. B. Clemons, J. P. Wilber, G. W. Young, A. G. Kang, M. J. Panzner, C. L. Cannon, Y. H. Yun, W. J. Youngs, N. M. Seckinger,* and E. K. Cope, “In vitro antimicrobial studies of silver carbene complexes: activity of free silver carbene complexes comparing with complexes incorporated into nanoparticles against clinical isolates of pathogenic bacteria,” Journal of Antimicrobial Chemotherapy, vol. 67 (1), p. 138-148, 2012. PMC3236053.

P. N. Shah, J. Smolen, A. Sen Gupta, and Y. H. Yun, “Electrospun pseudo poly(amino acids) for Tissue Engineering Applications,” in Nanotechnology in Tissue Engineering and Regenerative Medicine, K. Popat (ed.) Boca Raton: CRC Press LLC. ISBN: 9781439801413. Our data have been selected for the cover art.

Y. Cai, Y. H. Yun, and B. Z. Newby, “Generation of Contact-printing Based Poly(ethylene glycol) Gradient Surfaces with Micrometer-sized Steps,” Colloids and Surfaces B: Biointerfaces, vol. 75, p. 112-122, 2010. PMID: 19744840.

A. J. Ditto, P. N. Shah, and Y. H. Yun, “Non-viral gene delivery using nanoparticles,” Expert Opinion on Drug Delivery, vol 6(11), p. 1-12, 2009. PMID: 19780712.

P. N. Shah, A. A. Puntel, S. T. Lopina, and Y. H. Yun, “Development and in vitro cytotoxicity of microparticle drug delivery system for proteins using L-tyrosine polyphosphate,” Colloid and Polymer Science, vol. 287 (10), p. 1195-12-5, 2009. doi: 10.1007/s00396-009-2082-4.  

P. N. Shah, S. T. Lopina, and Y. H. Yun, “Blends of novel L-tyrosine based polyurethanes and polyphosphate for potential biomedical applications,” Journal of Applied Polymer Science, vol. 114 (5), p. 3235-3247, 2009. doi: 10.1002/app.30509.

A. J. Ditto, P. N. Shah, L. R. Gump and Y. H. Yun, “Nanospheres formulated from L-tyrosine polyphosphate exhibiting sustained release of polyplexes and in vitro controlled transfection properties,” Molecular Pharmaceutics, vol. 6 (3), p. 986-995, 2009. PMID: 19341289.

K. M. Hindi, A. J. Ditto, M. J. Panzner, D. A. Medvetz, D. S. Han, C. E. Hovis, J. K. Hillard, J. B. Taylor, Y. H. Yun,* C. L. Cannon,* W. J. Youngs,* “The antimicrobial efficacy of sustained release silver–carbene complex-loaded L-tyrosine polyphosphate nanoparticles: Characterization, in vitro and in vivo studies,” Biomaterials, vol. 30, p. 3771–3779, 2009. PMCID: PMC2801440. *Co-last authors.

P. N. Shah, R. L. Manthe, S. T. Lopina, and Y. H. Yun, “Electrospinning of L-tyrosine polyurethanes for potential biomedical applications,” Polymer, vol. 50, p. 2281-2289, 2009. doi: 10.1016/j.polymer.2009.02.048.

A. J. Ditto, P. N. Shah, S. T. Lopina, and Y. H. Yun, “Nanospheres Formulated from L-Tyrosine Polyphosphate as a Potential Intracellular Delivery Device,” International Journal of Pharmaceutics, vol. 368, p. 199-206, 2009. PMID: 19026734.

D. A. Medvetz, K. M. Hindi, M. J. Panzner, A. J. Ditto, Y. H. Yun and W. J. Youngs. “Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived From 4,5-dichloro-1H-imidazole," Metal-Based Drugs, vol. 2008, p. 1-7, 2008. PMCID: PMC2443426.

E. U. Azeloglu,* Y. H. Yun,* A. E. Saltman, I. B. Krukenkamp, F. Chiang, and W. Chen, and G. R. Gaudette “High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location,” Journal of Biomechanics, vol. 39 (4), p. 717-725, 2006. PMID: 16439241. *Co-first Authors.

Y. H. Yun, R. Chan, H. Liang, and W. Chen, “Sustained release of PEG-g-chitosan complexed DNA from poly(lactide-co-glycolide),” Journal of Biomaterials Science. Polymer Edition, vol. 16 (11), p. 1359-1378, 2005. PMID: 16372401.

A. Kim, P. Yellen, Y. H. Yun, E. U. Azeloglu, and W. Chen, “Delivery of a hyaluronan synthase gene via a crosslinked hyaluronan film,” Biomaterials, vol. 26 (13), p. 1585-1593, 2005. PMID: 15522760

Y. H. Yun, A. Kim, and W. Chen, “The application of derivatized hyaluronan for non-viral gene therapy,” Hyaluronan: Structure, Metabolism, Biological Activities, Therapeutic Applications", E. A. Balazs and V. C. Hascall (eds.) Matrix Biology Institute, p. 447-450, 2005.

Y. H. Yun and W. Chen, “Microspheres formulated from native hyaluronan for applications in gene therapy,” in Polymeric Gene Delivery: Principles and Applications, M. M. Amiji (ed.) Boca Raton: CRC Press LLC, p. 475-486, 2004.

Y. H. Yun, D. J. Goetz, P. Yellen, and W. Chen, “Hyaluronan microspheres for sustained gene delivery and site specific targeting,” Biomaterials, vol. 25 (1) p. 147-157, 2004. PMID: 14580918.

V. S. Patil, C. J. Campbell, Y. H. Yun, S. M. Slack, and D. J. Goetz, “Particle size influences adhesion under flow,” Biophysical Journal, vol. 80(4), p. 1733-1743, 2001. PMC1301363.

Y. H. Yun, V. T. Turitto, and J. I. Hochstein, “Porous Media modeling of flow in aneurysms treated with metallic coils,” Proceedings of the 1999 Heat Transfer Conference, HTD99-314, p. 1-11, 1999.

Y. H. Yun, V. T. Turitto, K. P. Daigle, P. Kovacs, J. A. Davidson, and S. M. Slack, “Initial hemocompatibility studies of titanium and zirconium alloys: prekallikrein activation, fibrinogen adsorption, and their correlation with surface electrochemical properties,” Journal of Biomedical Materials Research, vol. 32 (1), p. 77-85, 1996. PMID: 8864875.

Y. H. Yun, S. M. Slack, K. P. Daigle, J. A. Davidson, and V. T. Turitto, “Initial biocompatibility studies of novel titanium and zirconium alloys for cardiovascular applications,” Compatibility of Biomedical Implants, P. Kovacs and N. S. Istephanous (eds.) vol. 94(15), p. 105-115, 1994.

Abstracts

W. P. Qaqish, J. A. Smolen, Y. H. Yun, “The Emulsion Electrospinning of Biodegradable Polyurethane to Produce and Control Unique Polymer-Shell Morphologies,” Annals of Biomedical Engineering, (2012).

K. S. Shah, J. H. OverMeyer, W. Maltese, Y. H. Yun, “Hyaluronan Based Drug Pendant System for Delivery of Hydrophobic Drugs,” Annals of Biomedical Engineering, (2012).

K. N. Shah, J. A. Smolen, A. J. Ditto, D. C. Crowder, G. P Howard, N. W.  Halmagyi and Y. H. Yun, “DNA Condensate Morphology and Transfection, as Affected by Polycationic Strength,” Annals of Biomedical Engineering, (2012).

J. A. Smolen, K. N. Shah, P. N. Shah, R. L. Manthe, and Y. H. Yun, “The Emulsion Electrospinning of Biodegradable Polyurethane to Produce and Control Unique Polymer-Shell Morphologies,” The 2nd International Conference on Electrospinning 2012

A. J. Ditto, N. K. Robbishaw, M. J. Panzner, W. J. Youngs, Y. H. Yun, “Targeting ovarian cancer cells with rapidly biodegradable L-tyrosine polyphosphate nanoparticles decorated with folate,” Proceedings of the ASME 2011 Summer Bioengineering Conference, (2011).

A. J. Ditto, J. J. Reho, J. A. Smolen, J. H. Holda, R. J. Ramirez, and Y. H. Yun, “In vivo gene delivery with biodegrading nanoparticles,” Annals of Biomedical Engineering, (2010).

A. J. Ditto, N. K. Robishaw, M. J. Pazner, W. J. Youngs, and Y. H. Yun, “Bioegradable nanoparticles decorated with folate as a targeted anticancer therapeutic,” Annals of Biomedical Engineering, (2010).

A. J. Ditto, K. M. Hindi, M. J. Pazner, C. L. Cannon, W. J. Youngs, and Y. H. Yun, “Nanoparticles Loaded with Silver-Based Drugs as a Nebulizable Antimicrobial in the Chronically Infected Lungs of Cystic Fibrosis Patients,” Annals of Biomedical Engineering, (2009).

A. J. Ditto, N. K. Robishaw, M. J. Panzner, P. N. Shah, W. J. Youngs,  Y. H. Yun, “Folate Targeted Degradable Nanoparticles as an Anticancer Therapeutic ,” Annals of Biomedical Engineering, (2009).

P. N. Shah, J. A. Smolen, Y. H. Yun, “Electrospun Biodegradable L-tyrosine based Polyurethane Scaffolds for Biomedical Applications,” Annals of Biomedical Engineering, (2009).

Y. H. Yun, The next generation of antimicrobial nanoparticles,” 2nd Annual Meeting of the Center for Silver Therapeutics Research, (2009).

C. L. Cannon, D. S. Han, J. A. Taylor, C. E. Hovis, J. K. Hillard, A. J. Ditto, K. M. Hindi, M. J. Panzer, W. J. Youngs, and Y. H. Yun, ‘Nebulized nanoparticles loaded with broad-spectrum silver-based antimicrobials for depot treatment of pulmonary infections,” American Thoracic Society, (2009). American Thoracic Society has designated the subject of this abstract for a new release to journalists.

W. J. Youngs, N. Robishaw, M. J. Panzner, K. Hindi, D. A. Medvetz, J. Youngs, C. Tessier, A. J. Ditto, Y. H. Yun, J. Bauer, D. Lindner, “Treatment of breast cancer with silver antitumor drugs encapsulated in biodegradable polymeric nanoparticles,” Nanotech (2009).

Y. H. Yun, Formulation of Nanoparticles encapsulated with Silver Carbene Complexes,” 1st Annual Meeting of the Center for Silver Therapeutics Research, (2008).

A. J. Ditto, P. N. Shah, and Y. H. Yun, “Rapid biodegradable nanospheres designed for enhanced intracellular delivery of DNA,” Annals of Biomedical Engineering, (2008)

P. N. Shah, S. T. Lopina, Y. H. Yun, “Biocompatibility determination of novel L-tyrosine-based polyphosphates and polyurethanes.” Microscopy Society of Northeast Ohio, (2008). Winner of the best poster competition for graduate student in biological science


Education

Ph.D. in Engineering with Concentration in Bio Engineering, University of Memphis 1999; M.S. in Bio Engineering, University of Memphis, 1994; B.S. in ME, Christian Brothers University, 1989