Wiley J. Youngs

Research Interests

My research interests focus on:

• The development of new silver based antimicrobials for nebulization into the lung to combat bacterial lung infections.
• The formation of PLGA-PEG and LTP nanoparticles containing silver carbene complexes for the treatment of systemic bacterial  infections.
• The formation of PLGA-PEG and LTP nanoparticles with targeting groups such as folate on the surface for the treatment of cancers.
• The development of phosphazene polymers as proton conducting membrane materials for hydrogen fuel cells 

Selected Publications

1. Garrison, Jered C.; Youngs, W. J. "Ag(I) N-heterocyclic Carbene Complexes: Synthesis, Structure and Application" Chem. Rev. 2005, 3978-4008.
2. Kascatan-Nebioglu, Aysegul; Melaiye, Abdulkareem; Hindi, Khadijah; Durmus, Semih; Panzner, Matthew J.; Hogue, Lisa A.; Mallett, Rebekah J.; Hovis, Christine E.; Coughenour, Marvin; Crosby, Seth D.; Milsted, Amy; Ely, Daniel L.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J..   "Synthesis from Caffeine of a Mixed N-Heterocyclic Carbene-Silver Acetate Complex Active against Resistant Respiratory Pathogens"  Journal of Medicinal Chemistry  2006, 49, 6811-6818.
3. Medvetz, Doug A.; Sloan-Stakleff, Kimberly; Schreiber, Tara; Custer, Paul; Hindi, Khadijah; Panzner, Matthew J.; Blanco, Denise; Taschner, Michael J.; Tessier, Claire A.; Youngs, Wiley J. "Ovarian Cancer Cyclic Amine and Thiaether Metal Complexes",  Journal of Medicinal Chemistry 2007, 50, 1703-1706
4. Kascatan-Nebioglu, Aysegul; Panzner, Matthew J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J..   "N-Heterocyclic carbene-silver complexes: A new class of antibiotics",    Coordination Chemistry Reviews  2007,  251,  884-895.
5. Hindi, Khadijah M.; Siciliano, Tammy J.; Durmus, Semih; Panzner, Matthew J.; Medvetz, Doug A.; Reddy, D. Venkat; Hogue, Lisa A.; Hovis, Christine E.; Hilliard, Julia K.; Mallet, Rebekah J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J.   "Synthesis, Stability, and Antimicrobial Studies of Electronically Tuned Silver Acetate N-Heterocyclic Carbenes"    Journal of Medicinal Chemistry 2008,  51(6),  1577-1583. 
6. Medvetz, Doug A.; Hindi, Khadijah M.; Panzner, Matthew J.; Ditto, Andrew J.; Yun, Yang H.; Youngs; Wiley J. "Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole" Metal Based Drugs 2008, 384010, 7.