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Chemistry

Wiley J. Youngs

Research Interests

My research interests focus on:

  • The development of new silver based antimicrobials for nebulization into the lung to combat bacterial lung infections.
  • The formation of PLGA-PEG and LTP nanoparticles containing silver carbene complexes for the treatment of systemic bacterial  infections.
  • The formation of PLGA-PEG and LTP nanoparticles with targeting groups such as folate on the surface for the treatment of cancers.
  • The development of phosphazene polymers as proton conducting membrane materials for hydrogen fuel cells 

Selected Publications

  1. Garrison, Jered C.; Youngs, W. J. "Ag(I) N-heterocyclic Carbene Complexes: Synthesis, Structure and Application" Chem. Rev. 2005, 3978-4008.
  2. Kascatan-Nebioglu, Aysegul; Melaiye, Abdulkareem; Hindi, Khadijah; Durmus, Semih; Panzner, Matthew J.; Hogue, Lisa A.; Mallett, Rebekah J.; Hovis, Christine E.; Coughenour, Marvin; Crosby, Seth D.; Milsted, Amy; Ely, Daniel L.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J..   "Synthesis from Caffeine of a Mixed N-Heterocyclic Carbene-Silver Acetate Complex Active against Resistant Respiratory Pathogens"  Journal of Medicinal Chemistry  2006, 49, 6811-6818.
  3. Medvetz, Doug A.; Sloan-Stakleff, Kimberly; Schreiber, Tara; Custer, Paul; Hindi, Khadijah; Panzner, Matthew J.; Blanco, Denise; Taschner, Michael J.; Tessier, Claire A.; Youngs, Wiley J. "Ovarian Cancer Cyclic Amine and Thiaether Metal Complexes",  Journal of Medicinal Chemistry 2007, 50, 1703-1706
  4. Kascatan-Nebioglu, Aysegul; Panzner, Matthew J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J..   "N-Heterocyclic carbene-silver complexes: A new class of antibiotics",    Coordination Chemistry Reviews  2007251,  884-895.
  5. Hindi, Khadijah M.; Siciliano, Tammy J.; Durmus, Semih; Panzner, Matthew J.; Medvetz, Doug A.; Reddy, D. Venkat; Hogue, Lisa A.; Hovis, Christine E.; Hilliard, Julia K.; Mallet, Rebekah J.; Tessier, Claire A.; Cannon, Carolyn L.; Youngs, Wiley J.   "Synthesis, Stability, and Antimicrobial Studies of Electronically Tuned Silver Acetate N-Heterocyclic Carbenes"    Journal of Medicinal Chemistry 2008,  51(6),  1577-1583. 
  6. Medvetz, Doug A.; Hindi, Khadijah M.; Panzner, Matthew J.; Ditto, Andrew J.; Yun, Yang H.; Youngs; Wiley J. "Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole" Metal Based Drugs 2008, 384010, 7. 

Youngs Photo

WILEY J. YOUNGS

Distinguished Professor

B.A., 1972, SUNY at Albany
Ph.D., 1980, SUNY at Buffalo
Postdoctoral fellow, 1980-1983, Northwestern University
Assistant professor, 1983-1989, Case Western Reserve University
Associate Professor, 1989-1990, Case Western Reserve University

Office: KNCL 107
(330) 972-5362

Lab: KNCL 105, 109 & 211

Email: youngs@uakron.edu

Websites:

http://gozips.uakron.edu/~youngs

http://www.chemistry.uakron.edu/xray/

 

 

The University of Akron

Akron, OH 44325
Phone: 330-972-7111
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