Dr. Bruce Cushing

Dr. Bruce Cushing

Title: Professor
Department: Biology
Office: ASEC B235
Phone: 330-972-6018
Fax: 330-972-8445
Email: cbruce(at)uakron.edu


Biography

 I am an integrative biologist, with a specialty in Behavioral Neuroscience. I started out as a behavioral ecologist studying predator prey interactions. I was particularly interested in how behaviors associated with obtaining a mate (reproduction) increased vulnerability to predation. While I loved the theoretical aspects of this work I found myself continually drawn to understanding the mechanisms regulating behavior and how natural selection acted on the mechanisms. With that I started my journey into hormonal regulation and eventually into the brain, the ultimate regulator of behavior.

I maintain an active research program averaging 5 plus papers per year recent publications, and am always interested in having energetic students at both the graduate and undergraduate level participate in research. I am currently studying the role of steroids, primarily estrogen, and neuropeptides, oxytocin and vasopressin, in regulating the expression of social behavior. While I work with a number of species and conduct comparative research most of my current studies use the prairie vole Microtus ochrogaster. Prairie voles are a socially monogamous mammal, with a family based social system similar to many humans. There are also closely related species, such as the meadow vole, which are polygynous. This means that prairie voles are a good rodent model system for studying human biomedical issues, as well as basic comparative studies on function and expression of social behavior. We use a number of tools in our studies, including behavior, immunocytochemistry to label receptors and peptides production in the brain, molecular techniques, and viral vectors to regulate the expression of receptors in the brain. The following is a list of some of the specific areas of interest.

1. The role of estrogen receptors in regulating male social behavior. Estrogen acting via ER masculinizies male behavior. Therefore I am testing the hypothesis that for males to express high levels of social behavior there must be a reduction in ER in parts of the brain that regulate social behavior.

2. Developmental effects of oxytocin with an emphasis regulating steroidal responses and the expression of estrogen receptors. This is testing a novel hypothesis. In adults the effects of oxytocin are steroid dependent with estrogen increasing the effect. However I have hypothesized that during development that neuropeptides can regulate steroidal response.

3. We are using the prairie voles as a model system to study autism. Autism is associated with the significant deficits in social behavior and is much more common in males than females. By manipulating early neuropeptides and steroids we can examine the effects on social behavior, especially in males, to determine their possible role in the expression of mental health disorders.

4. I am also interested in epigenetic regulation of social behavior and the role of the early social environment in regulating the expression of social behavior and the effect on the underlying mechanisms.

Selected Publications

Intraspecific variation in estrogen receptor alpha and the expression of male sociosexual behavior in two population of prairie voles.

Central c-Fos expression in neonatal male and female prairie voles in response to treatment with oxytocin.

Estrogen receptor alpha distribution in male rodents is associated with social organization.

Neonatal castration inhibits adult male response to centrally-administered vasopressin but does not alter expression of V1a receptors.

Developmental effects of oxytocin on stress response: acute versus repeated exposure.

Neonatal manipulations of oxytocin affect reproductive behavior and reproductive success of adult female prairie voles.

Mechanisms underlying epigenetic effects of early social experience: the role of neuropeptides and steroids.

Neonatal manipulations of oxytocin alter expression of oxytocin and vasopressin immunoreactive cells in the paraventricular nucleus of the hypothalamus in a gender specific manner.

Vasopressin and estrogen receptor alpha in the paraventicular nucleus of the hypothalamus in Peromyscus.

Neonatal manipulation of oxytocin effects expression of estrogen receptor alpha.