Jeremy W. Prokop
Title: IB PhD Student
I am interested in the role of the Renin-Angiotensin system in the development of hypertension and cancer. Beginning with our labs past work with Sry, the testis determining protein, in elevation of blood pressure in the Spontaneously Hypertensive Rat, we have begun to expand these results into the human SRY system. As well, we now have some support that the homologous protein to Sry, Sox3, may likely play additional roles in blood pressure regulation. The new roles of Sox3 are of concern to post-menopausal women and Preeclampsia. I am beginning to expand our knowledge of Sox in blood pressure to other Sox genes besides Sry and Sox3.
The other aspect of my research is housed in a philosophical analysis of methodological reductionism. As molecular biology has been so valuable, many people have begun to reduce all knowledge down to the level of the gene and protein functions. This can often bias research aims and thus lead to an inductive tautology. To combat this, I have begun to identify anti-reductionist methods to combine with the normal molecular biology field. I have begun collaborations with many labs to work with structural aspects of the renin-angiotensin system, a system that is target of treatment for many hypertensive patients. This work is aimed at addressing treatment options to the entire system and not just individual components. Through using bioinformatics we can combine the knowledge of multiple organisms and multiple proteins to reach such a task. Using these techniques, we are also able to get a better understanding of protein-protein and protein-DNA interactions. I am currently looking at the interactions of Sox proteins with two different proteins, androgen receptor and KRAB (the most common repressor domain in the human genome).
Ohio Board of Regents, Bioinformatics Scholarship (2009-2012)
AHA Great Rivers Affiliate Predoctoral Fellowship (2011-2013)
Invited Seminar and lecturer to Universidade Federal de Minas Gerais, Brazil (2011)
International Society for hypertension New Investigator Poster Award (2011)
Who’s Who Among College and University Students (2008)
1). Prokop J, Watanabe IKM, Turner M, Milsted A. Human Sox3 is a potential regulator of the renin-angiotensin system. Hypertension. 2011, Accepted abstract.
2). Troyer S, Prokop J, Turner ME, Milsted A. Synergistic effects in gene regulation by human SRY and androgen receptor. Hypertension. 2011, Accepted abstract.
3). Prokop JW, Leeper T, Duan ZH, Milsted A. Amino acid function and docking site prediction through combining disease variants, structure alignments, sequence alignments, and molecular dynamics: A study of the HMG domain. BMC Bioinformatics. Accepted, 2011.
4). Prokop J, Watanabe IKM, Turner ME, Underwood AC, Martins AS, Milsted A. From rat to human, regulation of renin-angiotensin system genes by Sry. International Journal of Hypertension. In Press, http://www.hindawi.com/journals/ijht/aip/724240/
5). Turner ME, Ely D, Prokop J, Milsted A. Sry, more than testis determination? American Journal of Physiology- Regulatory, Integrative and Comparative Physiology. 2011, 301:(3) R561-R571.
6). Copeland DL, Duff RJ, Liu Q, Prokop J, Londraville RL. Leptin in Teleost Fishes: An Argument for Comparative Study. Frontiers in Aquatic Physiology. 2011, 2:26. doi:10.3389/fphys.2011.00026
7). Prokop J, Turner M, Milsted A. Sry regulation in the Renin-Angiotensin System. Hypertension. 2010, 56(5); E134.
BS Biology The University of Akron