Dr. Richard Londraville

Dr. Richard Londraville

Title: Professor
Dept/Program: Biology
Office: ASEC C312
Phone: 330-972-7151
Fax: 330-972-8445
Email: londraville@uakron.edu
Website: http://blogs.uakron.edu/londraville/


I'm a fish guy—I study how fish do what they do. I'm also a fat guy—I'm interested in what cells and organisms do with fat. Finally, I'm a temperature guy—I spend time thinking about how temperature affects cell function.

Together, these things mean that I study the cell physiology of fish with different body temperatures, and different fat metabolisms. In the past I've worked on very cold fish (Antarctic fish) and fish that are cold seasonally (like striped bass). I've also worked on some fish that keep parts of their bodies warm (blue marlin). Where does fat come into the picture? Cold fish tend to accumulate fat. Why? How? That is some of the focus of our current research. We study proteins that may help the cell to burn fat, move it around, get rid of it or deposit it. Specifically, we are working on leptin, and enzymes that burn fat. Current directions include characterizing how leptin works in zebrafish and carp.

Currently I am working with 3 doctoral students in the new Integrated Bioscience Ph.D. program. Donnie Copeland is working on how leptin affects carp's physiology in their environment. He is particularly interested in response to stress and cold. Hope Ball is working with myself, Joel Duff, and Hans Thewissen at NEOUCOM. Her project is investigating the biology of leptin in Bowhead whales. Mark Dalman will join the lab this Fall, and he is going to be working on leptin physiology in zebrafish.

Common techniques we use in the lab include proteomics, quantitative PCR, immunoblotting, microinjection of morpholino oligonucleotides, etc. (the common molecular bag of tricks).

Visit my blog


1994 Ph.D. University of Maine, Orono

Selected Publications

Ball HC1, Stavarz MOldaker JUsip SLondraville RLGeorge JCThewissen JGDuff RJ. 2015. Seasonal and ontogenetic variation in subcutaneous adipose of the bowhead whale (Balaena mysticetus). Anat Rec (Hoboken). 2015 Feb 24. doi: 10.1002/ar.23125. [Epub ahead of print]

Dores RM1, Londraville RL2, Prokop J2, Davis P2, Dewey N2, Lesinski N2. 2014. Molecular evolution of GPCRs: Melanocortin/melanocortin receptors. J Mol Endocrinol. 2014 Jun;52(3):T29-42. doi: 10.1530/JME-14-0050.

Prokop JW1, Schmidt C2, Gasper D2, Duff RJ2, Milsted A2, Ohkubo T3, Ball HC2, Shawkey MD2, Mays HL Jr4, Cogburn LA5, Londraville RL2. 2014. Discovery of the elusive leptin in birds: identification of several ‘missing links’ in the evolution of leptin and its receptor. PLoS One. 2014 Mar 24;9(3):e92751. doi: 10.1371/journal.pone.0092751. eCollection 2014.

Londraville RL1, Macotela Y2, Duff RJ3, Easterling MR4, Liu Q3, Crespi EJ4. 2014. Comparative endocrinology of leptin: assessing function in a phylogenetic contextGen Comp Endocrinol. 2014 Jul 1;203:146-57. doi: 10.1016/j.ygcen.2014.02.002. Epub 2014 Feb 11.

Dalman MR, Liu Q, King MD, Bagatto B and Londraville RL (2013) Leptin expression affects metabolic rate in zebrafish embryos (D. rerio)Front. Physiol. 4:160. doi: 10.3389/fphys.2013.00160

Ball, H.C., Holmes, R.K., Londraville, R.L. Thewissen, J.G.M., Duff, R.J. 2013. Leptin in Whales: Validation and measurement of mRNA expression by absolute quantitative real-time PCR. PLOS One. 8(1) e542771-11.

Prokop, J.W., R.J. Duff, H.C. Ball, D.L. Copeland, R.L. Londraville. 2012. Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides 38:326-336

Chen, Y., Londraville, R.L., Brickner, S., El-Shaar, L., Fankhauser, K., Dearth, C., Fulton, L. Sochacka, A., Bhattarai, S., Marrs, J.A., Liu, Q., 2012. Protocadherin-17 function in zebrafish retinal development. Dev. Neurobiol.  Aug 28 doi: 10.1002/dneu.22053

Q. Liu, M. Dalman, Y. Chen, M. Akhter, S. Brahmandam, Y. Patel, J. Lowe, M. Thakkar, A. Gregory, D. Phelps, C. Riley, and R.L. Londraville. 2012. Knockdown of leptin A expression dramatically alters zebrafish development. Gen. Comp. Endocrinol.  178 (3) 562-572.

D. L. Copeland, R.J. Duff, Q. Liu, J. Prokop, and R.L. Londraville. 2011. Leptin in Teleost Fishes: An Argument for Comparative Study. Front. Aquat. Physiol. June 2011 Vol 2 Article 26

R.L. Londraville and Niewiarowski, P.H. 2010. Leptin signaling systems in reptiles and amphibians. In: Leptin in Non-Mammalian Vertebrates. Ed. by M. Paolucci. Published by Research Signpost, Kerala, India.

Londraville, R.L. and P.H. Niewiarowski. 2009. Leptin signaling systems in reptiles and amphibians. In: Leptin in Non-Mammalian Vertebrates. Ed. by M. Paolucci. Published by Research Signpost, Kerala, India. In press.

Heflin, B., Young, L., and R. Londraville. 2009. Short-term cycling of skin colouration in the blackspotted rockskipper Entomacrodus striatus. J. Fish Biol. 74: 1635-1641.

Jury, D.R., Kaveti, S., Duan, Z-H, Willard, B., Kinter, M. and R. Londraville. 2008. Effects of calorie restriction on the zebrafish proteome. Comp. Biochem. Physiol. D. 3:275-282.

Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G. Fatkins. 2008. Cadherin-6 function in zebrafish retinal development. Develop. Neurobiol. 68(8):1107-1122.

Liu, B., R.J. Duff, R.L. Londraville, J.A. Marrs and Q. Liu. 2007. Cloning and expression analysis of cadherin 7 in the central nervous system of the embryonic zebrafish. Gene Express. Patterns 7 (1-2): 15-22

Spanovich, S., P.H. Niewiarowski, and R. L. Londraville. 2006. Seasonal effects on circulating leptin in the lizard Sceloporus undulatus from two populations. Comp. Biochem. Physiol. 143(4): 507-513.

Crockett, E.L. and R. L. Londraville. 2005. Temperature. pp. 231-269. In: The Physiology of Fishes 3rd Edition. Ed. by D.H. Evans abd J.B. Crc Press, Boca Raton, FL.

Liu Q, and R. L. Londraville. 2003. Using adult zebrafish visual system to study cadherin-2 expression during central nervous system regeneration. Methods Cell Sci. 00:1-8.

Liu Q., R.L. Londraville, E. Azodi, S.G. Babb, C. Chiappini, J.A. Marrs, and P. A. Raymond. 2002. Up-Regulation of Cadherin-2 and Cadherin-4 in Regenerating Visual Structures of Adult Zebrafish. Exp. Neurology 177:396-406.

Tschantz, D.R., E.L. Crockett, P.H. Niewiarowski, and R.L. Londraville. 2002. Cold acclimation strategy is highly variable among the sunfishes (Centrarchidae) Physiol. Biochem. Zool. 75:544-556.

Johnson, R.M.,T.M. Johnson, and R.L. Londraville. 2000. Evidence for leptin expression in fishes. J. Exp. Zool. 286(7):718-724